The White Sox went into the ninth inning at Guaranteed Rate Field down two runs to the Orioles.
One out away from a loss, Tommy Pham drove a ball into deep center field, but Orioles center fielder Colton Cowser incredibly robbed the home run to clinch the win over the South Side.
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The White Sox will take on the Orioles for the third game of this four-game series on Saturday at 1:10 p.m.